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, Guilherme Moura Cunha, MD MRI Department, Clínica de Diagnóstico por Imagem CDPI-DASA , Rio de Janeiro , Brazil Search for other works by this author on: Oxford Academic Kevin J Glaser, PhD Department of Radiology, Mayo Clinic , Rochester, MN , USA Search for other works by this author on: Oxford Academic Anke Bergman, PhD Programa de Carcinogênese Molecular, Instituto Nacional de Câncer (INCA) , Rio de Janeiro , Brazil Search for other works by this author on: Oxford Academic Rodrigo P Luz, MD Hepatology, Universidade Federal do Rio De Janeiro, UFRJ, Cidade Universitária , Rio de Janeiro , Brazil Search for other works by this author on: Oxford Academic Eduardo H de Figueiredo, B.Eng. MR Advanced Applications-Research , GE Healthcare, Latin America , São Paulo , Brazil Search for other works by this author on: Oxford Academic Flavia Paiva Proença Lobo Lopes, MD, PhD MRI Department, Clínica de Diagnóstico por Imagem CDPI-DASA , Rio de Janeiro , Brazil Radiology Department, School of Medicine, Universidade Federal do Rio de Janeiro UFRJ , Rio de Janeiro , Brazil Search for other works by this author on: Oxford Academic
British Journal of Radiology, Volume 91, Issue 1087, 1 July 2018, 20180126, https://doi.org/10.1259/bjr.20180126
Published:
17 May 2018
Article history
Received:
31 January 2018
Revision received:
24 March 2018
Revision received:
24 April 2018
Accepted:
25 April 2018
Published:
17 May 2018
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Guilherme Moura Cunha, Kevin J Glaser, Anke Bergman, Rodrigo P Luz, Eduardo H de Figueiredo, Flavia Paiva Proença Lobo Lopes, Feasibility and agreement of stiffness measurements using gradient-echo and spin-echo MR elastography sequences in unselected patients undergoing liver MRI, British Journal of Radiology, Volume 91, Issue 1087, 1 July 2018, 20180126, https://doi.org/10.1259/bjr.20180126
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Objective:
To evaluate the agreement of three MR elastography (MRE) sequences in patients undergoing liver MRI for clinical care.
Methods:
A cross-sectional retrospective study was performed with 223 patients referred for liver MRI, including 12 patients with liver iron overload. Data obtained with spin-echo (SE) and gradient-echo (GRE) MRE sequences were compared. Multiple linear regression adjusted for the presence of liver fat was also performed to assess the correlation between fat infiltration and stiffness measurements results. Agreement between two SE sequences was assessed in patients with liver iron overload.
Results:
We found strong correlation between the GRE sequence and two SE sequences. Spearman's correlation coefficients between the GRE, SE, and SE-EPI MRE sequences in patients with liver R2* <75Hz were 0.74, 0.81, and 0.80. GRE-MRE failed in patients with liver R2* > 75 Hz. In this subgroup, the correlation coefficient between both SE-MRE sequences was 0.97. Liver fat did not interfere with the results.
Conclusion:
In clinical setting, there is a high correlation between the GRE and SE MRE stiffness measurements, independently of the degree of liver fat infiltration measured by PDFF. A strong correlation between SE-MRE sequences is found even in patients with iron overload.
Advances in knowledge:
Our study addresses liver iron and fat content simultaneously to describing the technical feasibility and correlation between different MRE sequences in consecutive unselected patients refereed for liver MRI. EPI SE-MRE should be considered an optimal alternative to assess liver fibrosis in patients in whom GRE-MRE failures, such as iron-overloaded, in pediatric, elderly, or severely ill populations.
© 2018 The Authors. Published by the British Institute of Radiology
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Subject
Gastrointestinal
Issue Section:
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